ABSTRACT
Urinary tract infection in pregnancy leads to poor pregnancy outcome. Diagnosis and treatment of asymptomatic bacteriuria markedly improves pregnancy outcome as well as reduce the incidence of acute pyelonephritis. To determine the prevalence and bacteriology of asymptomatic bacteriuria among Antenatal patients in our centre; and to know if routine screening will be justifiable. This was a prospective study carried out between April and August 2008. Sample size was statistically determined.Women who consented were interviewed and mid stream urine samples were collected and processed in the microbiology laboratory; using standard microbiological methods. Out of 357 women studied; 65(18.21) had significant bacteriuria. was the commonest isolate (25.6); while was the least frequent isolate (3.66). Women in third trimester had the highest prevalence (25.68) while those in the first trimester had the least (15.79).Women that had only primary education had the highest prevalence (27.50) while those that had tertiary education had the least prevalence (21.10). The prevalence of significant asymptomatic bacteriuria among the women studied was high. Screening of all the pregnant women and treatment will reduce the incidence and complications of overt urinary tract infection in pregnancy among these women
Subject(s)
Bacteriology , Bacteriuria , Hospitals , Prenatal Care , Prevalence , TeachingABSTRACT
Starch obtained from Dioscorea dumetorium was employed as a disintegrant in Sodium Salicylate based tablets at concentrations of 5 -15w/w. Properties of the starch evaluated include: bulk and tapped densities; water uptake by capillarity; Hausner's quotient and percent compressibility. Compound tablets were evaluated for hardness; friability; disintegration time and dissolution rate. Batches of tablets containing equivalent concentrations of AC-di-sol or maize starch were employed as standards. Results obtained indicate that Dioscorea dumetorium starch performed as much better as a disintegrant in sodium salicylate tablets as maize starch but less than Ac-di-sol
Subject(s)
Dioscorea , Sodium Salicylate , StarchABSTRACT
In this study; the effects of some environmental storage conditions -light; temperature and humidity on the stability of the steroidal drug; hydrocortisone sodium succinate injection were investigated. The drug samples were stored at varying conditions of light; temperature (0OC; 28OC and 60OC) and humidity; after which each sample was assayed at weekly intervals for their content of the drug using a UV -Vis spectrophotometer. From the results obtained; storage under light; at enhanced temperature and in the presence of moisture had pronounced degradative effects on the stability of hydrocortisone sodium succinate injection; calling for caution in the storage of this widely used anti-allergic and anti-inflammatory drug
Subject(s)
Drug Stability , Drug Storage , Hydrocortisone , InjectionsABSTRACT
Compatibility of four brands of gentamicin sulphate injection with five parenteral drugs-dexamethasone; diazepam; hyoscine butylbromide; furosemide and promethazine were studied. These drugs are commonly used together in pre-anaesthetic or post-anaesthetic medications among others. For the different test situations; solutions of varying concentrations of gentamicin sulphate were prepared and mixed with the test drugs. After the test period; all the admixtures were evaluated for gentamicin potency; Ph changes; clarity and extent of interaction. Potency changes were determined by microbial assays while the extend of interaction was determined by chromatographic techniques. No significant changes in pH were observed in all the admixture studied. A significant reduction in potency was observed in all the admixtures of Gentarad. No significant interactions were observed based on the chromatographic studies